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Title:Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins
Author(s):Lee, Keng Jin
Doctoral Committee Chair(s):Leckband, Deborah E.
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Engineering, Chemical
Abstract:Finally, fluorescence imaging assessed cadherin clustering and actin organization in E-cadherin expressing cells cultured on E-, N-, and C-cadherin ectodomains. As expected, the formation of filamentous actin correlated with the Rac activation amplitudes in E-cadherin expressing cells. The results also showed that lateral cadherin clustering, which is thought to be an initial response to cadherin ligation, occurs in E-cadherin expressing cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may play a greater role in cell sorting than the biophysical properties of bonds between ectodomain subtypes.
Issue Date:2008
Description:121 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
Other Identifier(s):(MiAaPQ)AAI3337841
Date Available in IDEALS:2015-09-25
Date Deposited:2008

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