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Title:Microfluidic Platforms for Investigating Cell Migration
Author(s):Silvestre, Jonathan
Doctoral Committee Chair(s):Leckband, Deborah E.; Kenis, Paul J.A.
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Engineering, Chemical
Abstract:Furthermore, these studies quantified the relative effects of E-cadherin expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic mammary epithelial tumor cells MDA-MB-231. These investigations show that increased E-cadherin expression reduces cell motility by both adhesion-dependent and adhesion-independent mechanisms. By controlling both the substratum composition and E-cadherin expression we defined conditions that favor either the adhesion-independent or the adhesion-dependent mechanism of motility suppression.
Issue Date:2008
Description:153 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
Other Identifier(s):(MiAaPQ)AAI3337924
Date Available in IDEALS:2015-09-25
Date Deposited:2008

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