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Title:Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery
Author(s):Brodbeck, Kevin J.
Doctoral Committee Chair(s):McHugh, Anthony J.
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Pharmacy
Abstract:Protein burst on injection was entirely eliminated when the protein particle was densified with stearic acid and placed in a slow phase-inverting depot formulation. Particle densification can potentially be used with any protein or highly soluble drug agent, unlike other techniques that are protein specific. Taking advantage of the effects of low aqueous affinity and densification, a PLGA solution depot was produced that sustained serum hGH levels in normal rats at 10 to 200 ng/mL for 28 days.
Issue Date:1999
Type:Text
Language:English
Description:147 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
URI:http://hdl.handle.net/2142/82471
Other Identifier(s):(MiAaPQ)AAI9952973
Date Available in IDEALS:2015-09-25
Date Deposited:1999


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