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Title:Interactions Between Polyethylene Glycol Chains and Proteins and Chemically Selective Surfaces
Author(s):Sheth, Shailesh Rameshchandra
Doctoral Committee Chair(s):Deborah Leckband
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Physical
Abstract:The results presented in this work directly demonstrate that far from presenting an inert and repulsive steric barrier, PEG brushes can interact differently with different chemically selective surfaces. Clearly, PEG is not an inert, simple polymer whose biological activity, especially, vis-a-vis proteins, can be solely described via descriptions of 'simple' polymers such as the excluded volume or scaling theory. Rather, these studies show that its biological response is coupled to the specific physico-chemical attributes of its segments and hence, to the competitive interactions between the solvent and other entities such as non-polar groups on the protein surface for the chain segments.
Issue Date:1999
Description:130 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
Other Identifier(s):(MiAaPQ)AAI9953136
Date Available in IDEALS:2015-09-25
Date Deposited:1999

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