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Title:Neurochemical Mechanisms in the Hypothalamus and Attenuation of Compensatory Hormone Responses to Recurrent Hypoglycemia
Author(s):De Vries, Martin Goos
Doctoral Committee Chair(s):J. Lee Beverly
Department / Program:Neuroscience
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Pathology
Abstract:For the purpose of testing this hypothesis a new rat model of recurrent hypoglycemia was used in combination with in vivo microdialysis. This enabled the simultaneous evaluation of circulating glucose and hormones, as well as extracellular concentrations of glucose and norepinephrine (NE) in discrete hypothalamic nuclei. It was demonstrated that attenuated autonomic activation to recurrent hypoglycemia in rats is not caused by a previously presumed maladaptive increase of glucose uptake by the brain. The fall in brain glucose concentration is proportional to that in the blood, and this fall is not prevented during recurrent hypoglycemia. Moreover, noradrenergic neurotransmitter systems in the hypothalamus are activated to a decrease in ambient glucose, and their responsiveness is preserved after recurrent daily hypoglycemic episodes on three consecutive days. From the present work it became evident that the observed increase in liver glycogen content after recurrent hypoglycemia plays an essential role in the development of hypoglycemia unawareness. In contrast to fed controls, compensatory hormone responses during recurrent hypoglycemia were not attenuated when liver glycogen was depleted after an overnight fast. It is suggested that increased hepatic glycogen facilitates restoration of euglycemia, and thus alleviates extrahepatic compensatory processes.
Issue Date:2002
Description:121 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
Other Identifier(s):(MiAaPQ)AAI3070287
Date Available in IDEALS:2015-09-25
Date Deposited:2002

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