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Title:Engineering and Characterization of a Single Chain Antibody Specific for Murine CD28
Author(s):Orr, Brent Alan
Doctoral Committee Chair(s):Roy, Edward J.
Department / Program:Neuroscience
Discipline:Neuroscience
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Immunology
Abstract:Finally, a novel method of measuring the thermal stability of engineered antibody fragments using yeast surface display and flow cytometry was produced. This method allowed for the rapid determination of relative temperature stability without the need to produce large quantities of protein. This method compared favorably to other methods relying on soluble proteins and will facilitate the engineering and characterization recombinant proteins in the future.
Issue Date:2007
Type:Text
Language:English
Description:139 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/82515
Other Identifier(s):(MiAaPQ)AAI3269995
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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