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Title:Functional Peptidomics: Combining Discovery-Based Mass Spectrometry and Neurophysiology to Explore Communication of Phase -Resetting Cues in the Rat Suprachiasmatic Nucleus
Author(s):Atkins, Norman, Jr
Doctoral Committee Chair(s):Martha L. Gillette
Department / Program:Neuroscience
Discipline:Neuroscience
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Physiology
Abstract:This thesis justifies functional peptidomics as a useful approach to understanding intercellular signaling mechanisms regulating SCN clock phase. Directly detecting dynamic release properties of peptides from the SCN brain slice provides new insights on a complex phenomenon phenomenon. The identification and characterization of little SAAS serves as an example of the facets of SCN physiology left to be discovered. Utilization of peptidomics strategies will significantly advance understanding of timing homeostatic mechanisms.
Issue Date:2009
Type:Text
Language:English
Description:187 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
URI:http://hdl.handle.net/2142/82529
Other Identifier(s):(MiAaPQ)AAI3391876
Date Available in IDEALS:2015-09-25
Date Deposited:2009


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