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Title:Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
Author(s):Sendemir-Urkmez, Aylin
Doctoral Committee Chair(s):Russell D. Jamison
Department / Program:Materials Science and Engineering
Discipline:Materials Science and Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Engineering, Biomedical
Abstract:Cell loaded tissue engineered constructs were produced in vitro at clinically relevant sizes and implanted with and without bFGF into a porcine mandibular defect model. Tissue engineered constructs facilitated the healing of mandibular defects only if combined with delivery of bFGF via gelatin microspheres. bFGF release from the constructs improved neovascularization in the defect area and subsequently enhanced new bone formation. Although the rate and extent of bone formation was similar in bFGF group to those in empty defects for the period of the study, existence of woven bone in bFGF group suggests that bone formation is continuing while the lamellar structure in empty defects indicates that bone formation in that group was finalized.
Issue Date:2006
Type:Text
Language:English
Description:159 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
URI:http://hdl.handle.net/2142/82798
Other Identifier(s):(MiAaPQ)AAI3250320
Date Available in IDEALS:2015-09-25
Date Deposited:2006


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