Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes

Deszo, Eric Louis

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Title:	Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes
Author(s):	Deszo, Eric Louis
Doctoral Committee Chair(s):	Freund, Gregory G.
Department / Program:	Animal Sciences
Discipline:	Animal Sciences
Degree Granting Institution:	University of Illinois at Urbana-Champaign
Degree:	Ph.D.
Genre:	Dissertation
Subject(s):	Health Sciences, Pathology
Abstract:	The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.
Issue Date:	2003
Type:	Text
Language:	English
Description:	145 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
URI:	http://hdl.handle.net/2142/83551
Other Identifier(s):	(MiAaPQ)AAI3086046
Date Available in IDEALS:	2015-09-25
Date Deposited:	2003