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Description
Title: | Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes |
Author(s): | Deszo, Eric Louis |
Doctoral Committee Chair(s): | Freund, Gregory G. |
Department / Program: | Animal Sciences |
Discipline: | Animal Sciences |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Health Sciences, Pathology |
Abstract: | The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity. |
Issue Date: | 2003 |
Type: | Text |
Language: | English |
Description: | 145 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003. |
URI: | http://hdl.handle.net/2142/83551 |
Other Identifier(s): | (MiAaPQ)AAI3086046 |
Date Available in IDEALS: | 2015-09-25 |
Date Deposited: | 2003 |
This item appears in the following Collection(s)
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Dissertations and Theses - Animal Sciences
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois