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Title:The Analysis, Characterization and the Chemical Syntheses of C(20) and C(22) Cyclic Fatty Acid Monomers Formed in Heated Fish Oil
Author(s):Nzai, Jane Mbithe
Doctoral Committee Chair(s):Perkins, Edward G.
Department / Program:Food Science and Human Nutrition
Discipline:Food Science and Human Nutrition
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Agricultural
Abstract:Chemical synthesis of C$\sb{20}$ and C$\sb{22}$ CFAMs was carried out to enable (1) the determination of their physical and chemical properties, (2) to provide standards for the identification and characterization of CFAMs present in heated fish oils and (3) to make available pure standards for use in biological studies. Cyclopentyl and cyclohexyl CFAMs were synthesized to enable the identification of different cyclic fatty acids formed from both eicosapentaenoic and docosahexaenoic acids, C$\sb{20}$ and C$\sb{22}$ CFAMs respectively. Synthetic routes were developed to maximize the yield of both the intermediates and final products. Optimization of the chemical synthesis was carried out using the response surface methodology. Gas chromatography-mass spectrometry, high resolution $\sp1$H nuclear magnetic resonance and fourier transform infra-red spectrometry were used for structural verification of intermediates and final products.
Issue Date:1997
Type:Text
Language:English
Description:140 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/83721
Other Identifier(s):(MiAaPQ)AAI9737209
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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