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Title:Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2
Author(s):Guo, Ziwen
Doctoral Committee Chair(s):Nishida, Toshiro
Department / Program:Food Science and Human Nutrition
Discipline:Food Science and Human Nutrition
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Biochemistry
Abstract:Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-$\beta$ HDL and $\alpha$-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-$\beta$ HDL and $\alpha$-HDL.
Issue Date:1997
Description:107 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
Other Identifier(s):(MiAaPQ)AAI9812606
Date Available in IDEALS:2015-09-25
Date Deposited:1997

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