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Description
Title: | Multivariable Modeling and Control of the Response to Anesthesia |
Author(s): | Lin, Hui-Hung |
Doctoral Committee Chair(s): | Beck, Carolyn |
Department / Program: | Mechanical Engineering |
Discipline: | Mechanical Engineering |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Health Sciences, Medicine and Surgery |
Abstract: | To address these shortcomings, this dissertation proposes the use of piecewise-linear multivariable models of the effects of anesthetic and stimuli inputs on patient vital signs. These models are developed by utilizing data-based system identification methods. Different model structures such as linear time invariant (LTI), piecewise linear switching and parameter-varying, are investigated and verified. Robust gain scheduled controllers are constructed and simulated using a linear parameter varying (LPV) framework. The use of multivariable state-space models for patient modeling is novel in this research area, as is the proposed use of piecewise-linear models. The modeling results indicate that the proposed piecewise-linear models yield improved simulation responses over traditional PK-PD models, in comparisons made with respect to single-output effects. Further, individual models may provide reasonable central models in the sense that simulated output responses obtained by applying the input data set for one volunteer to the piecewise-linear models for other volunteers produces an acceptable fit to the output data for the first volunteer. Similar results are found for our constructed individual controllers when applied as a generic controller for other volunteer data. |
Issue Date: | 2006 |
Type: | Text |
Language: | English |
Description: | 170 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. |
URI: | http://hdl.handle.net/2142/83850 |
Other Identifier(s): | (MiAaPQ)AAI3223655 |
Date Available in IDEALS: | 2015-09-25 |
Date Deposited: | 2006 |
This item appears in the following Collection(s)
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Dissertations and Theses - Mechanical Science and Engineering
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois