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Title:Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells
Author(s):Yang, Shengyuan
Doctoral Committee Chair(s):Saif, M. Taher A.
Department / Program:Mechanical Engineering
Discipline:Mechanical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biophysics, General
Abstract:Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension.
Issue Date:2007
Description:106 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
Other Identifier(s):(MiAaPQ)AAI3290440
Date Available in IDEALS:2015-09-25
Date Deposited:2007

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