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Description
Title: | Synthesis and Reactivity of Electroactive Carbon Sulfide Ligands and Studies on Modifications of Nucleic Acids |
Author(s): | Holloway, Geoffrey Alan |
Doctoral Committee Chair(s): | Rauchfuss, Thomas B. |
Department / Program: | Chemistry |
Discipline: | Chemistry |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Chemistry, Inorganic |
Abstract: | Finally, a separate study into the selective selenization of nucleic acid oligonucleotides was pursued. By using the soluble Se-transfer agent (i-PrC5H4)2TiSe5 in a new method with solid-phase phosphoramidite oligonucleotide synthesis, a mono-, di-, tri-, and tridecanucleotide of DNA with one phosphoroselenoate modification as well as a dinucleotide of RNA modified with one phosphoroselenoate were synthesized. The utility of phosphate backbone modifications in nucleic acid chemistry has been pursued for phosphorothioates and may now be studied for selenium analogues. |
Issue Date: | 2001 |
Type: | Text |
Language: | English |
Description: | 134 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001. |
URI: | http://hdl.handle.net/2142/84040 |
Other Identifier(s): | (MiAaPQ)AAI3023076 |
Date Available in IDEALS: | 2015-09-25 |
Date Deposited: | 2001 |
This item appears in the following Collection(s)
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Dissertations and Theses - Chemistry
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois