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Title:Synthesis and Reactivity of Electroactive Carbon Sulfide Ligands and Studies on Modifications of Nucleic Acids
Author(s):Holloway, Geoffrey Alan
Doctoral Committee Chair(s):Rauchfuss, Thomas B.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Inorganic
Abstract:Finally, a separate study into the selective selenization of nucleic acid oligonucleotides was pursued. By using the soluble Se-transfer agent (i-PrC5H4)2TiSe5 in a new method with solid-phase phosphoramidite oligonucleotide synthesis, a mono-, di-, tri-, and tridecanucleotide of DNA with one phosphoroselenoate modification as well as a dinucleotide of RNA modified with one phosphoroselenoate were synthesized. The utility of phosphate backbone modifications in nucleic acid chemistry has been pursued for phosphorothioates and may now be studied for selenium analogues.
Issue Date:2001
Type:Text
Language:English
Description:134 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
URI:http://hdl.handle.net/2142/84040
Other Identifier(s):(MiAaPQ)AAI3023076
Date Available in IDEALS:2015-09-25
Date Deposited:2001


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