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Title:Mechanistic Investigations and Synthetic Development of (-)-Sparteine Mediated Asymmetric Benzylic Lithiation-Substitution Reactions of Secondary Amides
Author(s):Laumer, Jason Matthew
Doctoral Committee Chair(s):Beak, Peter
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:The synthetic utility of the lithiation-substitutions of N-(2-phenethyl)isobutyramide has also been investigated. Enantioenriched substituted products have been carried forward in the synthesis of 1,4-disubstituted dihydro- and tetrahydroisoquinolines. Variation of either substituent is convenient as the 4-position substituent is determined by choice of the electrophile in the lithiation-substitution and the 1-position substituent is introduced prior to cyclization.
Issue Date:2001
Type:Text
Language:English
Description:159 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.
URI:http://hdl.handle.net/2142/84057
Other Identifier(s):(MiAaPQ)AAI3030451
Date Available in IDEALS:2015-09-25
Date Deposited:2001


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