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Title:Novel Mass Spectrometric and Sampling Strategies for Investigating Neuropeptide Processing and Distribution
Author(s):Kruse, Rebecca Anne
Doctoral Committee Chair(s):Sweedler, Jonathan V.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Neuroscience
Abstract:Direct mass spectrometric analysis, combined with knowledge of expressed genes, often provides enough information to identify peptides, to determine new processing pathways, and to assess genetic variations. In some instances, however, alternative sampling approaches such as microseparation with MALDI MS detection are necessary to pre-concentrate and partially purify neuropeptides and to reduce ionization suppression effects. Here we describe the use of capillary electrophoresis (CE) coupled with complementary detection schemes MALDI MS and radionuclide detection for the determination of trace expression of neuropeptides in the cerebral ganglion A cluster.
Issue Date:2002
Type:Text
Language:English
Description:170 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84082
Other Identifier(s):(MiAaPQ)AAI3070360
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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