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Title:Lewis Base Catalyzed Enantioselective Aldol Additions: Preparative and Mechanistic Studies
Author(s):Pham, Son Minh
Doctoral Committee Chair(s):Denmark, Scott E.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Kinetic studies using ReactIR and rapid injection NMR (RINMR) spectroscopy have confirmed the existence of dual mechanistic pathways involving either one or two phosphoramides. Determination of Arrhenius activation parameters revealed that aldol addition occurs through the reversible albeit unfavorable formation of an activated complex. Finally, natural abundance 13C NMR kinetic isotope effect (KIE) studies have determined aldolization to be rate limiting.
Issue Date:2002
Type:Text
Language:English
Description:336 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84088
Other Identifier(s):(MiAaPQ)AAI3070414
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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