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Title:Mechanistic Studies and Synthetic Applications of Phosphite Dehydrogenase
Author(s):Vrtis, Jennifer Marie
Doctoral Committee Chair(s):van der Donk, Wilfred A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Cytochrome c oxidase, an enzyme that catalyzes the reduction of oxygen to water, has a binuclear center as well as a unique post-translational modification in the active site. Specifically, there is a crosslink between the nitrogen (Nepsilon2) of His240 and the carbon (Cepsilon 2) of Tyr244 (numbers correspond to CcO from bovine heart). The significance of the linkage was investigated by comparing the physicochemical properties of a model compound, 2-(imidazolyl-1-yl-4-methylphenol) to p-cresol.
Issue Date:2002
Type:Text
Language:English
Description:134 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002.
URI:http://hdl.handle.net/2142/84091
Other Identifier(s):(MiAaPQ)AAI3070466
Date Available in IDEALS:2015-09-25
Date Deposited:2002


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