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Title:Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
Author(s):Tamrazi, Anobel
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biophysics, Medical
Abstract:By attaching the fluorophore directly onto the ligand-binding domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray crystallography and NMR spectroscopy.
Issue Date:2003
Type:Text
Language:English
Description:153 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
URI:http://hdl.handle.net/2142/84109
Other Identifier(s):(MiAaPQ)AAI3086195
Date Available in IDEALS:2015-09-25
Date Deposited:2003


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