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Title:Top Down Mass Spectrometry of Archaea and Human Tumor Cells
Author(s):Forbes, Andrew James
Doctoral Committee Chair(s):Kelleher, Neil L.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Analytical
Abstract:A final study was performed applying the top down platform to human HeLa tumor cells. Thirty-four proteins in all were identified, and >90% of these were fully characterized. Several proteins harbored post-translational modifications including N-terminal and internal acetylations, methylations, disulfide bonds, and protein truncations. Proteins were also characterized with known coding single nucleotide polymorphisms, alternative splice variants, and highly homologous gene family members.
Issue Date:2004
Type:Text
Language:English
Description:133 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
URI:http://hdl.handle.net/2142/84151
Other Identifier(s):(MiAaPQ)AAI3153294
Date Available in IDEALS:2015-09-25
Date Deposited:2004


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