Investigating the Tyrosine-Histidine Linkage in the Copper B Site of Cytochrome C Oxidase: Model Studies Utilizing a Zinc Imidazole-Phenol Containing Complex

Pesavento, Russell P.

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Title:	Investigating the Tyrosine-Histidine Linkage in the Copper B Site of Cytochrome C Oxidase: Model Studies Utilizing a Zinc Imidazole-Phenol Containing Complex
Author(s):	Pesavento, Russell P.
Doctoral Committee Chair(s):	van der Donk, Wilfred A.
Department / Program:	Chemistry
Discipline:	Chemistry
Degree Granting Institution:	University of Illinois at Urbana-Champaign
Degree:	Ph.D.
Genre:	Dissertation
Subject(s):	Chemistry, Inorganic
Abstract:	A chelating ligand (BPAIP) was synthesized incorporating an ortho substituted imidazole-phenol moiety. The resultant Zn(II) complex, [Zn(BPAIP)(Br)]+, was found to exhibit a decreased pK A (8.24) and increased oxidation potential relative to the unbound BPAIP. In addition, the stability of [Zn(BPAIP)(Br)]+ in buffered D2O was found to be pH dependent. The increased stability of [Zn(BPAIP)(Br)] + in buffered D2O at basic pH coincides with the experimentally determined pKA of the phenolic proton of BPAIP. This implies changes in the donating ability of the imidazole to Zn(II) as a result of the protonation state of the cross-linked phenol. Thus, the linkage could serve to make the imidazole a stronger ligand to Zn(II).
Issue Date:	2004
Type:	Text
Language:	English
Description:	113 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
URI:	http://hdl.handle.net/2142/84161
Other Identifier(s):	(MiAaPQ)AAI3153398
Date Available in IDEALS:	2015-09-25
Date Deposited:	2004