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Title: | Investigating the Tyrosine-Histidine Linkage in the Copper B Site of Cytochrome C Oxidase: Model Studies Utilizing a Zinc Imidazole-Phenol Containing Complex |
Author(s): | Pesavento, Russell P. |
Doctoral Committee Chair(s): | van der Donk, Wilfred A. |
Department / Program: | Chemistry |
Discipline: | Chemistry |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Chemistry, Inorganic |
Abstract: | A chelating ligand (BPAIP) was synthesized incorporating an ortho substituted imidazole-phenol moiety. The resultant Zn(II) complex, [Zn(BPAIP)(Br)]+, was found to exhibit a decreased pK A (8.24) and increased oxidation potential relative to the unbound BPAIP. In addition, the stability of [Zn(BPAIP)(Br)]+ in buffered D2O was found to be pH dependent. The increased stability of [Zn(BPAIP)(Br)] + in buffered D2O at basic pH coincides with the experimentally determined pKA of the phenolic proton of BPAIP. This implies changes in the donating ability of the imidazole to Zn(II) as a result of the protonation state of the cross-linked phenol. Thus, the linkage could serve to make the imidazole a stronger ligand to Zn(II). |
Issue Date: | 2004 |
Type: | Text |
Language: | English |
Description: | 113 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. |
URI: | http://hdl.handle.net/2142/84161 |
Other Identifier(s): | (MiAaPQ)AAI3153398 |
Date Available in IDEALS: | 2015-09-25 |
Date Deposited: | 2004 |
This item appears in the following Collection(s)
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Dissertations and Theses - Chemistry
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois