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Title:Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Author(s):Sheeley, Sarah Abigail
Doctoral Committee Chair(s):Sweedler, Jonathan V.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Analytical
Abstract:Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then utilized in the development of a method combining the specificity of an enzyme with liquid chromatography/mass spectrometry to locate novel D-amino acid-containing peptides in the central nervous system of Aplysia californica.
Issue Date:2004
Type:Text
Language:English
Description:106 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
URI:http://hdl.handle.net/2142/84171
Other Identifier(s):(MiAaPQ)AAI3160953
Date Available in IDEALS:2015-09-25
Date Deposited:2004


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