Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides

Sheeley, Sarah Abigail

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Title:	Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Author(s):	Sheeley, Sarah Abigail
Doctoral Committee Chair(s):	Sweedler, Jonathan V.
Department / Program:	Chemistry
Discipline:	Chemistry
Degree Granting Institution:	University of Illinois at Urbana-Champaign
Degree:	Ph.D.
Genre:	Dissertation
Subject(s):	Chemistry, Analytical
Abstract:	Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then utilized in the development of a method combining the specificity of an enzyme with liquid chromatography/mass spectrometry to locate novel D-amino acid-containing peptides in the central nervous system of Aplysia californica.
Issue Date:	2004
Type:	Text
Language:	English
Description:	106 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
URI:	http://hdl.handle.net/2142/84171
Other Identifier(s):	(MiAaPQ)AAI3160953
Date Available in IDEALS:	2015-09-25
Date Deposited:	2004