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Title:Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
Author(s):Miao, Hai
Doctoral Committee Chair(s):Sweedler, Jonathan V.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Neuroscience
Abstract:A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely moving rats appears dependent on stimulation parameters, causing differential regulation of the circadian systems.
Issue Date:2005
Type:Text
Language:English
Description:180 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
URI:http://hdl.handle.net/2142/84179
Other Identifier(s):(MiAaPQ)AAI3182442
Date Available in IDEALS:2015-09-25
Date Deposited:2005


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