Part I. A Novel Vitamin B(12) Catalyzed Carbon-Carbon Bond Forming Reaction: Mechanistic Investigations and Aryl Alkene Cyclization. Part II. Mechanistic Investigation of Prostaglandin H Synthase Through the Synthesis of Site Specifically Substituted Arachidonic Acids

McGinley, Christopher

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Title:	Part I. A Novel Vitamin B(12) Catalyzed Carbon-Carbon Bond Forming Reaction: Mechanistic Investigations and Aryl Alkene Cyclization. Part II. Mechanistic Investigation of Prostaglandin H Synthase Through the Synthesis of Site Specifically Substituted Arachidonic Acids
Author(s):	McGinley, Christopher
Doctoral Committee Chair(s):	van der Donk, Wilfred A.
Department / Program:	Chemistry
Discipline:	Chemistry
Degree Granting Institution:	University of Illinois at Urbana-Champaign
Degree:	Ph.D.
Genre:	Dissertation
Subject(s):	Chemistry, Biochemistry
Abstract:	Finally, the syntheses of site-specifically deuterated arachidonic acids containing a remote tritium label are reported. These radiolabeled substrates would allow the characterization of the initial radical intermediate for PGHS under aerobic conditions and enzyme turnover. The substrates could also be used to investigate other oxygenase enzymes, such as lipoxygenases and aspirin-treated PGHS.
Issue Date:	2005
Type:	Text
Language:	English
Description:	210 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
URI:	http://hdl.handle.net/2142/84194
Other Identifier(s):	(MiAaPQ)AAI3199081
Date Available in IDEALS:	2015-09-25
Date Deposited:	2005