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Title:An Improved Understanding of Bisphosphonates Through Computational Techniques
Author(s):Sanders, John
Doctoral Committee Chair(s):Oldfield, Eric
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.
Issue Date:2005
Type:Text
Language:English
Description:194 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
URI:http://hdl.handle.net/2142/84201
Other Identifier(s):(MiAaPQ)AAI3199132
Date Available in IDEALS:2015-09-25
Date Deposited:2005


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