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Title: | Aminocyclodextrin Ion Channels: Development of a Model for Ligand Gating and Investigations of the Effects of Channel Structure on *Transport Properties and Ion Selectivity |
Author(s): | Sanders, Rachel Sarah |
Doctoral Committee Chair(s): | Mary S. Gin |
Department / Program: | Chemistry |
Discipline: | Chemistry |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Chemistry, Organic |
Abstract: | While it was previously shown that a heptaaminopentabutylene glycol beta-cyclodextrin ion channel was highly active and selectively transported anions, the requirements for the number of aminopentabutylene glycol substitutions were not known. beta-Cyclodextrin channels with four and two aminopentabutylene glycol chains and beta-cyclodextrins substituted with a glycine-pentabutylene glycol conjugate were synthesized. Their ion transport properties were assessed with a fluorescence assay using the pH sensitive dye HPTS. The amino acid containing channel showed little activity, while the di- and tetraamino channels showed increasing activity with increasing substitution. The tetraamino channel showed selectivity for anion transport that followed the trend ClO4- > I- > NO3- > Br- > Cl-. The preferences for ClO4-, I-, NO3-, and Br- transport were roughly 32, 16, 7, and 2 times that of Na+, respectively. The rate of transport of Cl- was roughly equivalent to the rate of Na + transport. |
Issue Date: | 2006 |
Type: | Text |
Language: | English |
Description: | 155 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. |
URI: | http://hdl.handle.net/2142/84234 |
Other Identifier(s): | (MiAaPQ)AAI3223711 |
Date Available in IDEALS: | 2015-09-25 |
Date Deposited: | 2006 |
This item appears in the following Collection(s)
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Dissertations and Theses - Chemistry
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois