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Title:Synthesis and Study of Biomimetic Ion Channels: (1) Toward the Development of a Cyclic Peptide-Based Redox-Gated Channel, and (2) Investigations Into the Effect of Pore Size on the Ion Selectivity of an Aminocyclodextrin Channel
Author(s):Schmidt, Emily Grace
Doctoral Committee Chair(s):Mary S. Gin
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:To probe the correlation between pore size and ion selectivity, a channel with an alpha-cyclodextrin macrocycle was synthesized and its transport properties were compared with those of an analogous channel with a larger beta-cyclodextrin pore. The anion transport profile of the alpha-cyclodextrin channel (ClO 4- > I- > Br- > NO3- > Cl-) differed from that of its beta-cyclodextrin counterpart (ClO4 - > I- > NO3- > Br- > Cl-) in the order of bromide and nitrate transport rates. While quantitative comparisons could not be made between the rates of ion transport through the alpha- and beta-cyclodextrin channels, a number of qualitative differences were observed between the two sets of transport data. Namely, the smaller pore of the alpha-cyclodextrin channel appeared to bind Cl- in such a way as to restrict Na+ transport. In addition, the larger I- and ClO4- ions seemed to pass through channel-induced membrane defects rather than through the smaller pore of the alpha-cyclodextrin channel.
Issue Date:2007
Type:Text
Language:English
Description:154 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84264
Other Identifier(s):(MiAaPQ)AAI3270020
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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