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Title:Immobilization of Catalytic DNA for Advanced Materials and Sensors
Author(s):Wernette, Daryl Paul
Doctoral Committee Chair(s):Lu, Yi
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Analytical
Abstract:The DNAzyme was also immobilized on patterned glass surfaces via covalent attachment. Substrate-functionalized 100 nm polystyrene particles were then hybridized in the absence and presence of Pb2+. The result was the Pb2+-mediated tethering of particles onto patterned grids, where Pb2+ induced the cleavage of the DNAzyme complex and prevented assembly of the particles. The assembly of these advanced materials was monitored in real-time using laser diffraction and was characterized via scanning electron microscopy. Addition of 10 muM Pb2+ showed >99% inhibition of assembly.
Issue Date:2007
Type:Text
Language:English
Description:153 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84267
Other Identifier(s):(MiAaPQ)AAI3270048
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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