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Title:Small Molecule Rhenium Carbonyl Complexes: Model Integrated-Design Technetium Estrogen Receptor Ligands for Tumor Imaging
Author(s):Ackroyd, Nathan C.
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Radiology
Abstract:It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been developed. A modification of the cyclopentadienyl motif introduces a hydroxyl-substituted 2-pyridinylmethyl group onto the central ring. The inclusion of the pyridine moiety allows for displacement of one CO as the ligand wraps around the rhenium. The low electrophilicity of a beta-aryl-substituted-cyclopentenone has thus far been a complicating factor in the completion of these syntheses.
Issue Date:2007
Description:90 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
Other Identifier(s):(MiAaPQ)AAI3290163
Date Available in IDEALS:2015-09-25
Date Deposited:2007

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