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Title:Part I. The Synthesis and Study of Luminescent Polyglycerol Dendrimers. Part II. Adenine Receptors With Simultaneous Watson-Crick and Hoogsteen Binding
Author(s):McKay, Jonathan
Doctoral Committee Chair(s):Zimmerman, Steven C.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Part II discusses efforts to synthesize receptors that employ hydrogen bonds to both the Hoogsteen and Watson-Crick faces of adenine as a means of enhancing the molecular recognition of this important biomolecule. A number of design approaches were carried out to "clamp" the exocyclic amine group of adenine. Model studies in chloroform as well as computer modeling demonstrated that multiple contacts on each face were necessary to obtain increased affinity over Nature's chosen hydrogen-bonding partner to adenine, thymine. A promising bicyclic ligand for adenine was synthesized using this approach.
Issue Date:2007
Type:Text
Language:English
Description:183 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84274
Other Identifier(s):(MiAaPQ)AAI3290318
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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