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Title:Investigation of Phospholipid Bilayer Interactions With Substrates, Polymers, and Nanoparticles
Author(s):Spurlin, Tighe A.
Doctoral Committee Chair(s):Gewirth, Andrew A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Analytical
Abstract:The last experiments described investigate the ability of water dispersed fullerene aggregates to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water soluble fullerenes adhere to lipid headgroups and may disrupt cellular functions by either radical generation or cell membrane passivition.
Issue Date:2007
Type:Text
Language:English
Description:182 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/84281
Other Identifier(s):(MiAaPQ)AAI3290388
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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