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Title:Using Unnatural Amino Acids and Nonnative Cofactors for Metalloprotein Design and Engineering
Author(s):Garner, Dewain K.
Doctoral Committee Chair(s):Lu, Yi
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:Different positions for anchoring the salen cofactor to the Mb scaffold were observed to affect both the rate and selectivity of the artificial enzyme in a modular and accumulative fashion. Molecular dynamic simulations indicate that these changes may be due to the steric effects of the linker arms inside the protein cavity. The realization that the covalent anchors exert effects through interaction with substrates entering the pocket will help design better metalloproteins.
Issue Date:2008
Type:Text
Language:English
Description:164 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/84291
Other Identifier(s):(MiAaPQ)AAI3314772
Date Available in IDEALS:2015-09-25
Date Deposited:2008


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