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Title:Synthesis and Biological Evaluation of Coactivator Binding Inhibitors and Bivalent Ligands for the Estrogen Receptor
Author(s):LaFrate, Andrew
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Oncology
Abstract:The synthesis of steroidal bivalent ligands for ER is also reported. Two estradiol molecules were connected through a phenylethynyl linkage with chemical tethers of varying composition and length. The binding properties of the bivalent ligands for ER were measured. Moderate relative binding affinities were obtained and in some cases biphasic binding curves were observed.
Issue Date:2008
Type:Text
Language:English
Description:137 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/84316
Other Identifier(s):(MiAaPQ)AAI3337835
Date Available in IDEALS:2015-09-25
Date Deposited:2008


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