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Title:The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
Author(s):Thompson, Christina
Doctoral Committee Chair(s):Hergenrother, Paul J.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly quenching ROS. Dykellic acid was also found to not directly inhibit caspase enzymes, an important family of enzymes in cellular death. While the mechanism of action of dykellic acid has yet to be elucidated, dykellic acid's potency and apparently nonstandard mechanism of action make it an interesting candidate for evaluation in models of cytoprotection.
Issue Date:2008
Type:Text
Language:English
Description:198 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
URI:http://hdl.handle.net/2142/84331
Other Identifier(s):(MiAaPQ)AAI3347578
Date Available in IDEALS:2015-09-25
Date Deposited:2008


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