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Title:Palladium-Catalyzed Cross -Coupling Reactions of Organosilanolates: Methods Development and Application in the Total Synthesis of (+)-Papulacandin D
Author(s):Regens, Christopher
Doctoral Committee Chair(s):Denmark, Scott E.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Finally, an E,Z-1,4-bissilylbutadiene reagent was prepared for the synthesis of unsymmetrical, highly conjugated systems. Two distinct silyl substituents were differentiated in the cross-coupling reaction through the initial use of base-promoted reaction conditions where only one silyl group was reactive with a range of aryl halides. The second silyl substituent then reacted under fluoride-promoted reaction conditions to provide the desired unsymmetrical products.
Issue Date:2009
Type:Text
Language:English
Description:375 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
URI:http://hdl.handle.net/2142/84337
Other Identifier(s):(MiAaPQ)AAI3363072
Date Available in IDEALS:2015-09-25
Date Deposited:2009


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