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Title:Selective Targeting of RNA With Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops
Author(s):Meyer, Stephen Todd
Doctoral Committee Chair(s):Hergenrother, Paul J.
Department / Program:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Organic
Abstract:Hairpin loops occur in a region of RNA that doubles back on itself, leaving several unpaired bases at the terminus of a duplexed region. Dimers of 2-deoxystreptamine are known to bind to this class of secondary structure. Certain functionalized napthyridines are also known to display the appropriate donor-acceptor relationship to have a selective hydrogen bonding interaction with guanine. An effort was undertaken to combine these two disparate types of binding to enhance the overall selectivity of the ligand. The resulting compounds extended the methodology for binding to hairpin loops, and expanded the available repertoire for the chemistry of naphthyridines.
Issue Date:2009
Description:152 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
Other Identifier(s):(MiAaPQ)AAI3392218
Date Available in IDEALS:2015-09-25
Date Deposited:2009

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