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Title:Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
Author(s):Hom, Roy Kay
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:Tetradentate oxorhenium(V) coordination motifs were subsequently investigated as possible modes by which the metal-chelate may be incorporated into a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a metal coordination sphere. A tetradentate oxorhenium(V) estradiol mimic was synthesized and exhibited much higher lipophilicity than the bis-bidentate DHT mimic, as well as sufficient stability to be assayed in vitro; however, it demonstrated low binding to the estrogen receptor.
Issue Date:1997
Type:Text
Language:English
Description:83 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/84365
Other Identifier(s):(MiAaPQ)AAI9737132
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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