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Title:Rotational Dynamics and Proton Relaxation of MRI Paramagnetic Contrast Agents
Author(s):Chen, John Wen-Yueh
Doctoral Committee Chair(s):Belford, R.L.; Clarkson, Robert B.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biophysics, Medical
Abstract:Rotational dynamics play an important role in determining the relaxation characteristics of paramagnetic contrast agents (PCA's) used in magnetic resonance imaging. In this work, a methodology employing continuous wave electron paramagnetic resonance spectroscopy has been developed and established to probe the rotational dynamics of model contrast agents. Rotational dynamics of model contrast agents have been determined, not only in an aqueous environment, where the agents tumble isotropically, but also in highly viscous environments (mirroring those that can be found within the body), where the agents undergo anisotropic motion. These results have been extended to study the rotational dynamics of PCA's covalently linked to dendrimers, non-covalently linked to human serum albumin, and taken up within rat hepatocytes. Dendrimeric contrast agents also tumble anisotropically. On the other hand, a two population model must be used to describe the rotational dynamics of contrast agents in a human serum albumin solution or a rat hepatocyte suspension. Proton relaxation of model agents, which utilized nuclear magnetic relaxation dispersion (NMRD), have also been studied for agents in these environments. Combining the results from the motional studies with careful analyses of the NMRD profiles, this work affirmed and established and significance of second-sphere relaxation as well as the physical models for proton relaxation of the model contrast agents in the environments studied. From these analyses, useful information has been extracted about the proton relaxation of the model agents that can be and have been used to effect rational design of paramagnetic contrast agents in the future.
Issue Date:1997
Type:Text
Language:English
Description:161 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/84375
Other Identifier(s):(MiAaPQ)AAI9812551
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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