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Title:Application of Chemiluminescent Detection to a Capillary Electrophoresis System Contained on a Glass Slide and the Development of Non-Flowing Electrogenerated Chemiluminescence Probes
Author(s):Preston, J. Patrick
Doctoral Committee Chair(s):Nieman, T.A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:A capillary electrophoresis system contained on a micromachined glass slide which integrates chemiluminescence as the detection method has been constructed and demonstrated as a feasible analytical technique. A simple method which does not require highly specialized facilities to manufacture these planar devices has concurrently been developed. This separation and detection system was characterized by separating and detecting mixtures of proline and tripropylamine. To further illustrate the applicability of this device, the anti-anxiety drug buspirone and its major metabolite 1-(2-pyrimidyl)piperazine were added to a human plasma matrix. The drug and metabolite were then separated from this matrix and detected.
Issue Date:1997
Type:Text
Language:English
Description:98 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.
URI:http://hdl.handle.net/2142/84389
Other Identifier(s):(MiAaPQ)AAI9812742
Date Available in IDEALS:2015-09-25
Date Deposited:1997


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