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 Title: Synthetic Chiral Stationary Phases in Enantioselective Liquid Chromatography Author(s): Gan, Kevin Ze Doctoral Committee Chair(s): Pirkle, William H. Department / Program: Chemistry Discipline: Chemistry Degree Granting Institution: University of Illinois at Urbana-Champaign Degree: Ph.D. Genre: Dissertation Subject(s): Chemistry, Analytical Abstract: The occurrence of $\pi - \pi$ face to face and $\pi - \pi$ face to edge interactions on a particular type of chiral stationary phase (CSP) used for chromatographic separations of enantiomers has been studied. Highly polarizable aromatic substituents, such as halogens, have been found to enhance $\pi - \pi$ face to face interactions and can be used in the designs of new CSPs so as to improve their enantioselectivity. The structural elements required for successful enantioseparations of hydantoins and thiohydantoins were systematically investigated with the aforementioned CSP. Additionally, a new CSP in its family was rationally designed and synthesized in an attempt to optimize its chromatographic performance. Issue Date: 1998 Type: Text Language: English Description: 99 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998. URI: http://hdl.handle.net/2142/84397 Other Identifier(s): (MiAaPQ)AAI9834677 Date Available in IDEALS: 2015-09-25 Date Deposited: 1998
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