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 Title: Molecular Recognition of Nucleic Acids Author(s): Thiessen, Paul Archer Doctoral Committee Chair(s): Zimmerman, Steven C. Department / Program: Chemistry Discipline: Chemistry Degree Granting Institution: University of Illinois at Urbana-Champaign Degree: Ph.D. Genre: Dissertation Subject(s): Biology, Molecular Abstract: Part II presents the design and attempted synthesis of several novel nucleosides that were intended to hydrogen bond to Watson-Crick base pairs in the major groove of DNA. The geometry of the connection of these heterocycles to the ribose backbone was designed to be isomorphous with the T$\cdot$AT and C$\sp+\cdot$GC base triplets of the Pyr$\cdot$Pur-Pyr triplex motif. The goal of this work was to improve the sequence generality of triple helix formation. In some cases the heterocycles could not be made, while in others the desired heterocycles were made, but attachment to the ribose for incorporation into DNA oligonucleotides was unsuccessful. Friedlander condensation with tetramic acids was shown to be a viable method for construction of the tricyclic portion of a CG host. Issue Date: 1998 Type: Text Language: English Description: 152 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998. URI: http://hdl.handle.net/2142/84405 Other Identifier(s): (MiAaPQ)AAI9834749 Date Available in IDEALS: 2015-09-25 Date Deposited: 1998
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