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Title:Design, Syntheses and Functional Studies of DNA Binding Metal Complexes
Author(s):Bauer, Cornelia
Doctoral Committee Chair(s):Wang, Andrew H.J.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Pharmaceutical
Abstract:Both cis- and trans- (Pt(NH$\sb3)\sb2$(4-Me-Py)Cl$\rbrack\sp+$ bind DNA covalently at the N7-site of the guanines forming a monodentate adduct, but only the cis-isomer has anticancer activity. The interactions of these platinum complexes with the DNA-heptamer d(CCTGTCC):d(GGACAGG) were examined and a NMR based high resolution structure was determined. Surprisingly both platinum-DNA complexes do not form a very stable complex with its complementary strand. Over time the platinum-DNA complex decomposes and either the 2-methyl-pyridinium group or the platinum complex itself is detached. No interstrand crosslinking was observed.
Issue Date:1998
Type:Text
Language:English
Description:158 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/84406
Other Identifier(s):(MiAaPQ)AAI9904391
Date Available in IDEALS:2015-09-25
Date Deposited:1998


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