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Title:Characterization of Solution Species Relevant to the Peroxidase-Nadh Biochemical Oscillator
Author(s):Lvovich, Vadim Florentij
Doctoral Committee Chair(s):Dissertation Abstracts International, Volume
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Engineering, Chemical
Abstract:The discovery of significance of iron-NADH complexation for the kinetics of NADH decomposition and oxidation led to an investigation of the influence of solution oxygen and biologically prominent metal ions on NADH degradation. Almost all metal ions under investigation appeared to complex quickly with NADH. Studies of kinetics of simultaneous processes of NADH acid-catalyzed decomposition, complexation, and oxidation in different environments were undertaken. It was observed that Fe2+ and Fe3+ were the only solution ions which caused a decrease in NADH decomposition rates, opposite to all other metal ions under investigation. The presence of metal ions accelerated NADH acid-catalyzed decomposition to a greater extent than NADH oxidation. Contrary to most literature sources, it was determined that the second, and not the first step of decomposition is rate-limiting. (Abstract shortened by UMI.).
Issue Date:1998
Type:Text
Language:English
Description:203 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/84413
Other Identifier(s):(MiAaPQ)AAI9904529
Date Available in IDEALS:2015-09-25
Date Deposited:1998


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