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Title:Labeling of Proteins, Peptides, and Estrogens With Cyclopentadienyltricarbonylrhenium and Technetium
Author(s):Spradau, Todd Walter
Doctoral Committee Chair(s):Katzenellenbogen, John A.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Inorganic
Abstract:The conjugation of cyclopentadienyltricarbonylrhenium to molecules having an affinity for the estrogen receptor is described. A variety of derivatives were prepared using either an indirect labeling or a preformed chelate approach, and of the compounds synthesized, ((17$\beta$-estradiol-17$\alpha$-yl)-ethynylcyclopentadienyl) tricarbonylrhenium and its 11$\beta$-chloromethyl, ethyl and methoxy derivatives are attractive candidates for imaging estrogen receptors in vivo, having relative binding affinities (RBA's) for the estrogen receptor of 7.29%, 283%, 283% and 52.6%, respectively.
Issue Date:1998
Type:Text
Language:English
Description:148 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998.
URI:http://hdl.handle.net/2142/84415
Other Identifier(s):(MiAaPQ)AAI9904593
Date Available in IDEALS:2015-09-25
Date Deposited:1998


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