Files in this item

FilesDescriptionFormat

application/pdf

application/pdf9944896.pdf (8MB)Restricted to U of Illinois
(no description provided)PDF

Description

Title:Studies on the Stereochemistry and Mechanism of Taxadiene Biosynthesis
Author(s):Jin, Qingwu
Doctoral Committee Chair(s):Coates, Robert M.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Enzyme-mediated cyclization of GPP, FPP, and GGPP goes through various carbocationic intermediates, and methoxy analogs of these substrates would provide strong stabilization towards the carbocation intermediates. Upon release from the enzyme, the non-natural products would provide valuable insights to the enzyme mechanisms that would otherwise be unavailable. Methoxy-substituted nor analogs of geraniol, farnesol, and geranylgeraniol were prepared by alkylation of carbanions generated from allylic ethers.
Issue Date:1999
Type:Text
Language:English
Description:236 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
URI:http://hdl.handle.net/2142/84445
Other Identifier(s):(MiAaPQ)AAI9944896
Date Available in IDEALS:2015-09-25
Date Deposited:1999


This item appears in the following Collection(s)

Item Statistics