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Title:Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors
Author(s):Koohang, Ali
Doctoral Committee Chair(s):Coates, Robert M.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:The enhanced inhibitory activities of these novel aziridine diphosphate and methanediphosphonates towards squalene synthase compared to the analogous acyclic azabifarnesyl diphosphate may indicate a bridged non-classical, protonated cyclopropane intermediate in the formation of presqualene diphosphate.
Issue Date:1999
Type:Text
Language:English
Description:223 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
URI:http://hdl.handle.net/2142/84447
Other Identifier(s):(MiAaPQ)AAI9944913
Date Available in IDEALS:2015-09-25
Date Deposited:1999


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