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Title:Mass Spectrometric Characterization of Peptides in Neurons
Author(s):Garden, Rebecca Wells
Doctoral Committee Chair(s):Sweedler, Jonathan V.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Analytical
Abstract:The MALDI-based approach is inherently different from conventional methods, in that essentially all peptides present at significant concentrations are detected, not only those which are pre-selected or radioactively tagged. Furthermore, single cells, nerves, and vesicles are screened without the need to isolate each peptide from its complex cellular environment. Sampling, data acquisition, and strategies for the generation of molecular ion images are presented which reveal the utility of MALDI MS for direct and rapid neuropeptide characterization.
Issue Date:1999
Type:Text
Language:English
Description:231 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
URI:http://hdl.handle.net/2142/84454
Other Identifier(s):(MiAaPQ)AAI9953020
Date Available in IDEALS:2015-09-25
Date Deposited:1999


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