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Title:Stereochemistry and Mechanism of the Enzyme-Catalyzed Cyclization of Geranylgeranyl Diphosphate to (-)-Abietadiene
Author(s):Ravn, Matthew M.
Doctoral Committee Chair(s):Coates, Robert M.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Biochemistry
Abstract:A novel double labelling experiment involving (15S,17 E)-[15-3H1,17-2H1] CPP gave [16-3H1,16-2H1] abietadiene where the stereochemistry of the methyl was established as R by degradation and enzymatic analysis of the generated chiral methyl acetic acid. This indicated a surprising syn facial relationship of the "intramolecular" proton transfer and methyl migration on the si face of the terminal olefin affected by rAS.
Issue Date:2000
Type:Text
Language:English
Description:444 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000.
URI:http://hdl.handle.net/2142/84469
Other Identifier(s):(MiAaPQ)AAI9955661
Date Available in IDEALS:2015-09-25
Date Deposited:2000


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