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Title:Part I. Cleavage of Carbamates to Isocyanates: Selectivity, Extension to the Solid Support, and Synthesis of Multivalent Glycoforms With Inter-Saccharide Carbamate Linkages. Part II. Conjugation of Carbohydrate Moieties to a Rigid Aromatic Linker for the Study of Glycoside Internal Dynamics
Author(s):Chong, Pek Y. Christine
Doctoral Committee Chair(s):Petillo, Peter A.
Department / Program:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Organic
Abstract:Part II. A synthetic protocol for the synthesis of carbohydrate-linker moieties that will allow conjugation of a saccharide to a protein is reported. This approach was demonstrated in the synthesis of the saccharide-linker moieties of the four glucopyranosyl-beta-D-glucopyranosides. The results show that disaccharides with varying glycosidic linkage positions may be functionalized with the aromatic linker by reduction of the anomeric azide group and acylation. With the completed synthesis of the desired glucopyranosyl glucopyranoside-linker moieties, protein conjugation requires the condensation of these hydrazides with a glyoxamide functionalized protein.
Issue Date:2000
Description:146 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000.
Other Identifier(s):(MiAaPQ)AAI9989962
Date Available in IDEALS:2015-09-25
Date Deposited:2000

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