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Title:Production and Surface Modification of Protein Microspheres
Author(s):Kufner, Gregory S.
Doctoral Committee Chair(s):Kenneth S. Suslick
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Health Sciences, Pharmacology
Abstract:Previous work by Leamon and Lee has shown the successful targeting of folate labeled polyethylene glycol (PEGylated) liposomes to tumors that express folate receptors. Adaptation of this technology allowed approximately 6000 folate-PEG polymers per microsphere to be covalently linked to the surface of the albumin microspheres. A flow cytometry assay with KB cells, which express high levels of folate receptor, was unable to detect specific targeting of the microspheres under flow cytometry conditions.
Issue Date:2000
Type:Text
Language:English
Description:175 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000.
URI:http://hdl.handle.net/2142/84485
Other Identifier(s):(MiAaPQ)AAI9990051
Date Available in IDEALS:2015-09-25
Date Deposited:2000


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